"The majority of SARS-CoV-2 variant mutations occur in that spike protein and so thus far, the ability of at-home [tests] to detect the virus has not been affected, through many interactions of changing variants, because the nucleocapsid protein has not changed much as the virus has evolved," Amy Karger, MD, PhD, clinical pathologist and associate professor at the University of Minnesota Medical School in Minneapolis, told Becker's. 

https://www.beckershospitalreview.com/public-health/are-tests-catching-xbb-1-16.html

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